Exploring the Function of Dynamic Phosphorylation-Dephosphorylation Cycles
نویسندگان
چکیده
منابع مشابه
Ultrasensitivity in Phosphorylation-Dephosphorylation Cycles with Little Substrate
Cellular decision-making is driven by dynamic behaviours, such as the preparations for sunrise enabled by circadian rhythms and the choice of cell fates enabled by positive feedback. Such behaviours are often built upon ultrasensitive responses where a linear change in input generates a sigmoidal change in output. Phosphorylation-dephosphorylation cycles are one means to generate ultrasensitivi...
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We consider a model for a network of phosphorylation-dephosphorylation cycles coupled through forward and backward regulatory interactions, such that a protein phosphorylated in a given cycle activates the phosphorylation of a protein by a kinase in the next cycle as well as the dephosphorylation of a protein by a phosphatase in a preceding cycle. The network is cyclically organized in such a w...
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Halakhor S1, Qujeq D2, Shikhpour R3 1. Instructor, Department of Biochemistry and Biophysics, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran 2. Associate professor, Department of Biochemistry and Biophysics, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran 3. GP, Babol, Iran Abstract Background: Previous reports show that phosphorylation anddepho...
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Phenylalanine hydroxylase (Ec 1.14.16.1) catalyses the initial step of phenylalanine degradation in man and other mammals. Although the liver is the primary location of the enzyme, an appreciable amount is also found in the renal cortex [I]. The regulatory properties of the hepatic enzyme are well known. In the short-term, enzymic activity is controlled by reversible phosphorylation [2]. Glucag...
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The phosphorylated intermediate (EP) of the Na,K-ATPase proteoliposomes (PL) prepared from the electric eel enzyme is composed of an ADP-sensitive K+-insensitive form (E1P), an ADP- and K+-sensitive form (E*P), and a K+-sensitive ADP-insensitive form (E2P). The composition of the intermediate varied with the cholesterol content of the lipid bilayer. The PL containing less than 30 mol % choleste...
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ژورنال
عنوان ژورنال: Developmental Cell
سال: 2018
ISSN: 1534-5807
DOI: 10.1016/j.devcel.2018.03.002